Ethyl 5-Oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate
نویسندگان
چکیده
Indolo[2,1-b]quinazolin-6,12-dione (tryptanthrin) derivatives present important types of nitrogen-containing heterocyclic compounds which are useful intermediate products in organic synthesis and have potential pharmaceutical applications. The new ethyl 5-oxo-5-(((12-oxoindolo[2,1-b]quinazolin-6(12H)-ylidene)amino)oxy)pentanoate (Compound 2) was synthesized. Compound 2 is the first example a tryptanthrin derivative containing dicarboxylic acid residue side chain. Z,E-isomerism investigated by DFT calculations. Bioavailability evaluated silico using ADME predictions. According to results, potentially highly bioavailable has prospective be used as main component for development anti-inflammatory drugs.
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ژورنال
عنوان ژورنال: Molbank
سال: 2022
ISSN: ['1422-8599']
DOI: https://doi.org/10.3390/m1451